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| Registros recuperados : 13 | |
| 3. |  | SAVOLDI, I. R.; PETRY, B.; CARMO, K. B. do; IBELLI, A. M. G.; PEIXOTO, J. de O.; LEDUR, M. C. Expressão do gene PTHLH em frangos de corte normais e afetados pela necrose da cabeça do fêmur. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 10., 2016, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2017. p. 13-14. JINC.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 4. | | PETRY, B.; IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; FIGUEIREDO, E. A. P. de; LEDUR, M. C. Padronização de um teste de diagnóstico molecular utilizando sondas Taqman® para a detecção do gene do Halotano em suínos. In: JORNADA INTEGRADA EM BIOLOGIA, 1, 2014, Joaçaba. Anais... Joaçaba: Unoesc, 2014.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 5. | | SAVOLDI, I. R.; PETRY, B.; CARMO, K. B. do; MARCIANO, C. M. M.; PEIXOTO, J. de O.; LEDUR, M. C. Seleção de genes constitutivos para estudos de expressão gênica em ossos de frangos de corte aos 35 dias de idade. In: JORNADA DE INICIAÇÃO CIENTÍFICA (JINC), 10., 2016, Concórdia. Anais... Brasília: Embrapa, 2016. p. 28-29.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 6. | | PETRY, B.; ZANELLA, R.; IBELLI, A. M. G.; MARCHESI, J. A. P.; PANDOLFI, J. R. C.; LEDUR, M. C.; PEIXOTO, J. de O. Comparação de métodos de homogeneização celular e congelamento para extração de RNA. In: JORNADA DE INICIAÇÃO CIENTÍFICA (JINC), 7., 2013, Concórdia. Anais... Brasília, DF: Embrapa, 2013. p. 13-14.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | PETRY, B.; SAVOLDI, I. R.; IBELLI, A. M. G.; PALUDO, E.; PEIXOTO, J. de O.; JAENISCH, F. R. F.; CUCCO, D. de C.; LEDUR, M. C. New genes involved in the Bacterial Chondronecrosis with Osteomyelitis in commercial broilers. Livestock Science, v. 208, p. 33-39, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 8. | | SAVOLDI, I. R.; PALUDO, E.; CARMO, K. B. do; PETRY, B.; IBELLI, A. M. G.; ONO, R. K.; PEIXOTO, J. de O.; LEDUR, M. C. Fatores que influenciam características de integridade óssea e expressão dos genes COL 1A2 e RAMKL em frangos de corte. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 10., 2016, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2017. p. 67-68. JINC.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | PETRY, B.; ZANELLA, R.; IBELLI, A. M. G.; FORNARI, M. B.; PANDOLFI, J. R. C.; CANTAO, M. E.; COUTINHO, L. L.; PEIXOTO, J. de O.; LEDUR, M. C. Unraveling the associations of SOST gene with production traits in an F2 Chicken Resource Population. In: CONGRESSO BRASILEIRO DE GENÉTICA, 59., 2013, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2013. p. 152.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 10. | | ROMANO, G. de S.; ZANELLA, R.; IBELLI, A. M. G.; PETRY, B.; TESSMANN, A. L.; PEIXOTO, J. de O.; PEDROSA, V. B.; PINTO, L. F. B.; LEDUR, M. C. Association of the RUNX2 gene with carcass traits in an F2 chicken population. In: CONGRESSO BRASILEIRO DE GENÉTICA, 61., 2015, Águas de Lindóia. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2015. p. 69.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 11. | | NOVAIS, F. J. DE; YU, H.; CESAR, A. S. M.; MOMEN, M.; POLETI, M. D.; PETRY, B.; MOURÃO, G. B.; REGITANO, L. C. de A.; MOROTA, G.; COUTINHO, L. L. Multi-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle. Frontiers in Genetics, v. 13, 948240, oct. 2022. 14 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 12. | | ONO, R. K.; PALUDO, E.; IBELLI, A. M. G.; PEIXOTO, J. de O.; PETRY, B.; PANDOLFI, J. R. C.; LOPES, L. dos S.; JAENISCH, F. R. F.; LEDUR, M. C. Fatores relacionados à variação na expressão gênica no fêmur de frangos de corte. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 12., 2017, Ribeirão Preto. Anais... Ribeirão Preto: SBMA, 2017. 1 CD-ROM.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 13. | | PETRY, B.; MOREIRA, G. C. M.; COPOLA, A. G. L.; SOUZA, M. M. de; VEIGA, F. C. da; JORGE, E. C.; PEIXOTO, J. de O.; LEDUR, M. C.; KOLTES, J. E.; COUTINHO, L. L. SAP30 gene is a probable regulator of muscle hypertrophy in chickens. Frontiers in Genetic, v. 12, n. 709937, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 13 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
17/11/2022 |
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Data da última atualização: |
17/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
NOVAIS, F. J. DE; YU, H.; CESAR, A. S. M.; MOMEN, M.; POLETI, M. D.; PETRY, B.; MOURÃO, G. B.; REGITANO, L. C. de A.; MOROTA, G.; COUTINHO, L. L. |
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Afiliação: |
FRANCISCO JOSÉ DE NOVAIS, Department of Animal Science, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil; HAIPENG YU, Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States; ALINE SILVA MELLO CESAR, Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Piracicaba, Brazil; MEHDI MOMEN, Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States; MIRELE DAIANA POLETI, Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, Brazil; BRUNA PETRY, Department of Animal Science, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil; GERSON BARRETO MOURÃO, Department of Animal Science, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; GOTA MOROTA, Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States; LUIZ LEHMANN COUTINHO, Department of Animal Science, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, Brazil. |
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Título: |
Multi-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 13, 948240, oct. 2022. |
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Páginas: |
14 p. |
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DOI: |
https://doi.org/10.3389/fgene.2022.948240 |
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Idioma: |
Inglês |
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Conteúdo: |
Data integration using hierarchical analysis based on the central dogma or common pathway enrichment analysis may not reveal non-obvious relationships among omic data. Here, we applied factor analysis (FA) and Bayesian network (BN) modeling to integrate different omic data and complex traits by latent variables (production, carcass, and meat quality traits). A total of 14 latent variables were identified: five for phenotype, three for miRNA, four for protein, and two for mRNA data. Pearson correlation coefficients showed negative correlations between latent variables miRNA 1 (mirna1) and miRNA 2 (mirna2) (-0.47), ribeye area (REA) and protein 4 (prot4) (-0.33), REA and protein 2 (prot2) (-0.3), carcass and prot4 (-0.31), carcass and prot2 (-0.28), and backfat thickness (BFT) and miRNA 3 (mirna3) (?0.25). Positive correlations were observed among the four protein factors (0.45?0.83): between meat quality and fat content (0.71), fat content and carcass (0.74), fat content and REA (0.76), and REA and carcass (0.99). BN presented arcs from the carcass, meat quality, prot2, and prot4 latent variables to REA; from meat quality, REA, mirna2, and gene expression mRNA1 to fat content; from protein 1 (prot1) and mirna2 to protein 5 (prot5); and from prot5 and carcass to prot2. The relations of protein latent variables suggest new hypotheses about the impact of these proteins on REA. The network also showed relationships among miRNAs and nebulin proteins. REA seems to be the central node in the network, influencing carcass, prot2, prot4, mRNA1, and meat quality, suggesting that REA is a good indicator of meat quality. The connection among miRNA latent variables, BFT, and fat content relates to the influence of miRNAs on lipid metabolism. The relationship between mirna1 and prot5 composed of isoforms of nebulin needs further investigation. The FA identified latent variables, decreasing the dimensionality and complexity of the data. The BN was capable of generating interrelationships among latent variables from different types of data, allowing the integration of omics and complex traits and identifying conditional independencies. Our framework based on FA and BN is capable of generating new hypotheses for molecular research, by integrating different types of data and exploring non-obvious relationships. MenosData integration using hierarchical analysis based on the central dogma or common pathway enrichment analysis may not reveal non-obvious relationships among omic data. Here, we applied factor analysis (FA) and Bayesian network (BN) modeling to integrate different omic data and complex traits by latent variables (production, carcass, and meat quality traits). A total of 14 latent variables were identified: five for phenotype, three for miRNA, four for protein, and two for mRNA data. Pearson correlation coefficients showed negative correlations between latent variables miRNA 1 (mirna1) and miRNA 2 (mirna2) (-0.47), ribeye area (REA) and protein 4 (prot4) (-0.33), REA and protein 2 (prot2) (-0.3), carcass and prot4 (-0.31), carcass and prot2 (-0.28), and backfat thickness (BFT) and miRNA 3 (mirna3) (?0.25). Positive correlations were observed among the four protein factors (0.45?0.83): between meat quality and fat content (0.71), fat content and carcass (0.74), fat content and REA (0.76), and REA and carcass (0.99). BN presented arcs from the carcass, meat quality, prot2, and prot4 latent variables to REA; from meat quality, REA, mirna2, and gene expression mRNA1 to fat content; from protein 1 (prot1) and mirna2 to protein 5 (prot5); and from prot5 and carcass to prot2. The relations of protein latent variables suggest new hypotheses about the impact of these proteins on REA. The network also showed relationships among miRNAs and nebulin proteins. REA seems to be the central no... Mostrar Tudo |
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Palavras-Chave: |
Bayesian network; Latent variables; Omics data. |
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Thesaurus NAL: |
Factor analysis; Meat quality. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1148406/1/MultiOmicDataIntegration.pdf
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Marc: |
LEADER 03242naa a2200313 a 4500
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008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fgene.2022.948240$2DOI
100 1 $aNOVAIS, F. J. DE
245 $aMulti-omic data integration for the study of production, carcass, and meat quality traits in Nellore cattle.$h[electronic resource]
260 $c2022
300 $a14 p.
520 $aData integration using hierarchical analysis based on the central dogma or common pathway enrichment analysis may not reveal non-obvious relationships among omic data. Here, we applied factor analysis (FA) and Bayesian network (BN) modeling to integrate different omic data and complex traits by latent variables (production, carcass, and meat quality traits). A total of 14 latent variables were identified: five for phenotype, three for miRNA, four for protein, and two for mRNA data. Pearson correlation coefficients showed negative correlations between latent variables miRNA 1 (mirna1) and miRNA 2 (mirna2) (-0.47), ribeye area (REA) and protein 4 (prot4) (-0.33), REA and protein 2 (prot2) (-0.3), carcass and prot4 (-0.31), carcass and prot2 (-0.28), and backfat thickness (BFT) and miRNA 3 (mirna3) (?0.25). Positive correlations were observed among the four protein factors (0.45?0.83): between meat quality and fat content (0.71), fat content and carcass (0.74), fat content and REA (0.76), and REA and carcass (0.99). BN presented arcs from the carcass, meat quality, prot2, and prot4 latent variables to REA; from meat quality, REA, mirna2, and gene expression mRNA1 to fat content; from protein 1 (prot1) and mirna2 to protein 5 (prot5); and from prot5 and carcass to prot2. The relations of protein latent variables suggest new hypotheses about the impact of these proteins on REA. The network also showed relationships among miRNAs and nebulin proteins. REA seems to be the central node in the network, influencing carcass, prot2, prot4, mRNA1, and meat quality, suggesting that REA is a good indicator of meat quality. The connection among miRNA latent variables, BFT, and fat content relates to the influence of miRNAs on lipid metabolism. The relationship between mirna1 and prot5 composed of isoforms of nebulin needs further investigation. The FA identified latent variables, decreasing the dimensionality and complexity of the data. The BN was capable of generating interrelationships among latent variables from different types of data, allowing the integration of omics and complex traits and identifying conditional independencies. Our framework based on FA and BN is capable of generating new hypotheses for molecular research, by integrating different types of data and exploring non-obvious relationships.
650 $aFactor analysis
650 $aMeat quality
653 $aBayesian network
653 $aLatent variables
653 $aOmics data
700 1 $aYU, H.
700 1 $aCESAR, A. S. M.
700 1 $aMOMEN, M.
700 1 $aPOLETI, M. D.
700 1 $aPETRY, B.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
700 1 $aMOROTA, G.
700 1 $aCOUTINHO, L. L.
773 $tFrontiers in Genetics$gv. 13, 948240, oct. 2022.
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Embrapa Pecuária Sudeste (CPPSE) |
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